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Although this overall dosage created plasma sildenafil concentrations which ended up roughly 2 to five instances larger when compared to the signify maximum plasma concentrations subsequent one oral dose of a hundred mg in healthy male volunteers, the hemodynamic response to physical exercise was preserved in these sufferers.
The imply profiles of the improve from baseline in standing systolic hypertension in subjects handled with doxazosin together with twenty five mg VIAGRA or matching placebo are shown in Determine 2.
Numerous of these activities have been documented to arise for the duration of or shortly soon after sexual activity, and a few were being claimed to occur Soon immediately after the usage of VIAGRA without having sexual activity. Many others ended up noted to have happened hours to times soon after the use of VIAGRA and sexual action. It's not possible to find out no matter whether these occasions are similar on to VIAGRA, to sexual exercise, towards the client's underlying cardiovascular disease, to a mix of these factors, or to other aspects [see WARNINGS AND Safety measures and PATIENT Details].
The most typical Negative effects of VIAGRA: headache; flushing; upset stomach; irregular vision, such as variations in shade vision (for instance getting a blue coloration tinge) and blurred vision; stuffy or runny nose; again ache; muscle mass ache; nausea; dizziness; rash.
VIAGRA contains sildenafil, which is similar medicine located in An additional drug known as REVATIO. REVATIO is made use of to deal with a rare condition known as pulmonary arterial hypertension (PAH).
Drug Interactions: For concomitant utilization of remedies That could be contraindicated or for dose adjustment (at baseline And through treatment method)
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The AUC with the Lively metabolite, N-desmethyl sildenafil, was greater sixty two% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These outcomes to the metabolite are certainly not predicted to get of medical consequence.
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This analysis was done retrospectively, and was not run to detect any pre-specified distinction in adverse reactions.